The effectiveness of tissue-perfusion-guided resuscitation in shock : A systematic review and meta-analysis

Tissue-perfusion-guided therapy (TP-GT) showed no difference in short- or long-term mortality compared with standard care. Although it did not improve survival, TP-GT significantly reduced fluid volume during early resuscitation and possibly shortened ICU LOS. TP-GT may contribute to personalized shock management. However, further research should determine the best-performing tissue-perfusion assessment methods and identify specific patient phenotypes that may benefit most from this approach.

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Beyond blood pressure : a comprehensive overview of clinical indices in shock and tissue hypoperfusion