Why we may need higher doses of beta-lactam antibiotics : introducing the ‘maximum tolerable dose’ ( An Magriet Dhaese S. et al.)

Hello everybody, 

Here is a theoretical approach of how increasing uremic toxin concentrations could be used as a quantifiable marker of beta-lactam antibiotic toxicity.

Remember that in critically ill patients there is a low beta-lactam antibiotic concentrations due to PK variability. This has led to the adoption of prolonged infusion to increase target attainment.

Try to implement the concept of maximum tolerable dose about beta-lactam antibiotic in your daily practice.

Thanks to the authors.

Article review

Original article

Regards,

Frédéric Caruso, M.D