Pathophysiological implications of ventriculo-arterial coupling in septic shock

Jun 13

Given that septic shock patients often have impaired cardiovascular reserve, a more personalized approach to therapy, tailored based on volume responsiveness and VA coupling, may be essential to achieve efective and efficient resuscitation from severe sepsis. Integrating bedside assessment of Ea and Ees with dynamic indexes of fuid responsiveness provides a multi-modality approach that enhances our understanding of the pathophysiology and should guide personalized management of the severe hemodynamic instability seen in septic shock.